Partager

Réponses immunologiques chez les rats WKA après cryochirurgie du fibrosarcome provoqué par le 3-méthylcholanthrène (KMT-17), plus une synthèse de la cryoimmunologie.

[In Japanese. / En japonais.]

Auteurs : SHIBATA T., SUZUKI K., YAMASHITA T.

Type d'article : Article

Résumé

The authors studied immunological responses following cryosurgery using 3-methylcholanthrene induced fibrosarcoma KMT-17 and reported the modulation of anti-tumour immunity after cryosurgery. In this paper, the authors desrcribed the summary of their results and discussed the cryo-immunology against the malignant tumour. When tumour bearing rats were traited by cryosurgery, pulmonary metastasis was enhanced by cryosurgery and both immuno-suppression in the early phase and enhanced transplantation resistance to KMT-17 tumour cells in the late phase following cryosurgery were observed. This enhancement of pulmonary metastasis was markedly reduced by surgical removal of cryo-necrotized tumour tissues, while implantation of cryo-necrotized tumour tissues into the rats treated with surgical excision developed pulmonary metastasis. Anti-tumour activity of spleen cells obtained from rats treated with cryosurgery was reduced as compared with that of rats treated with surgical excision, though this phenomenon completely disappeared by anti-T treatment of spleen cells. These results strongly suggest that immuno-suppression following cryosurgery is caused by suppressor T cells.

Détails

  • Titre original : [In Japanese. / En japonais.]
  • Identifiant de la fiche : 2004-2518
  • Langues : Japonais
  • Source : Low Temperature Medicine - vol. 28 - n. 1
  • Date d'édition : 03/2002
  • Document disponible en consultation à la bibliothèque du siège de l'IIF uniquement.

Liens


Voir d'autres articles du même numéro (10)
Voir la source

Indexation