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Application de méthodes analytiques et de systèmes modélisés dans la lyophilisation de biomolécules complexes.

The application of analytical methods and model systems in the lyophilization of complex biomolecules.

Auteurs : MATEJTSCHUK P., MALIK K. P., DURU C., et al.

Résumé

NIBSC produces primary biological reference materials from a wide range of sources, including sera, cell culture, purified proteins, nucleic acids and carbohydrates, and from complex preparations including viral lysates and cellular materials. Most of these standards are lyophilized to provide assured stability over a shelf life of many years. Many of these preparations have multi-component formulations and over recent years, the authors have applied a wide range of analytical methods to determine the critical thermal transitions and eutectic properties. Low residual moisture and controlled container properties are also essential to maintain this prolonged storage stability and the authors' experiences in these areas is shared. The presentation is illustrated by reference to both model systems and processed standards which have enabled them to arrive at a rational approach to the challenges of manufacturing such a wide range of lyophilized reference materials.

Documents disponibles

Format PDF

Pages : 2007-3

Disponible

  • Prix public

    20 €

  • Prix membre*

    Gratuit

* meilleur tarif applicable selon le type d'adhésion (voir le détail des avantages des adhésions individuelles et collectives)

Détails

  • Titre original : The application of analytical methods and model systems in the lyophilization of complex biomolecules.
  • Identifiant de la fiche : 2008-2754
  • Langues : Anglais
  • Source : New Ventures in Freeze-Drying
  • Date d'édition : 07/2007

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